2-Fluoro-5-Hydroxymethylphenylboronic Acid

2-Fluoro-5-Hydroxymethylphenylboronic Acid - Names and Identifiers

Name	(2-Fluoro-5-(hydroxymethyl)phenyl)boronicacid
Synonyms	3-BORONO-4-FLUOROBENZYL ALCOHOL 2-Fluoro-5-HydroxymethylphenylboronicAci 2-Fluoro-5-Hydroxymethylphenylboronic Acid 2-FLUORO-5-HYDROXYMETHYLPHENYLBORONIC ACID (2-Fluoro-5-(hydroxymethyl)phenyl)boronicacid 2-FLUORO-5-(HYDROXYMETHYL)BENZENEBORONIC ACID Boronic acid, B-[2-fluoro-5-(hydroxymethyl)phenyl]-
CAS	1072952-25-0
InChI	InChI=1S/C7H8BFO3/c9-7-2-1-5(4-10)3-6(7)8(11)12/h1-3,10-12H,4H2

2-Fluoro-5-Hydroxymethylphenylboronic Acid - Physico-chemical Properties

Molecular Formula	C7H8BFO3
Molar Mass	169.95
Melting Point	70-72°C
Appearance	Crystallization
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
MDL	MFCD06656276

2-Fluoro-5-Hydroxymethylphenylboronic Acid - Risk and Safety

Hazard Symbols	C - Corrosive
Hazard Class	IRRITANT

2-Fluoro-5-Hydroxymethylphenylboronic Acid - Introduction

2-Fluoro-5-hydroxymethylphenylboronic acid is an organic compound with the chemical formula C7H7BFO3. The following is a description of its nature, use, preparation and safety information:

Nature:
2-Fluoro-5-hydroxymethylbenzeneboronic acid is a white or light yellow crystalline solid, soluble in water and organic solvents. Its pH value is low, weak acid.

Use:
2-Fluoro-5-hydroxymethylphenylboronic acid is often used as a reagent in organic synthesis. It can participate in various organic synthesis reactions such as boronic acid-catalyzed substitution reactions and metal-catalyzed coupling reactions. In addition, it can also be used as a precursor of functional materials for the preparation of fluorescent dyes, coatings, rubber additives, etc.

Preparation Method:
The preparation method of 2-fluoro-5-hydroxymethylphenylboronic acid is relatively simple. A common synthetic method is the heating reaction of 5-hydroxymethylsalicylic acid with boron trifluoride in the presence of hydrofluoric acid to produce the target product. Attention should be paid to operating conditions and safety protection during preparation.

Safety Information:
2-Fluoro-5-hydroxymethylphenylboronic acid is relatively stable under general operating conditions, but it is still necessary to comply with safe operating procedures. In case of contact with skin, eyes or inhalation, rinse immediately with plenty of water and seek medical assistance. During storage and handling, keep away from fire and oxidant to avoid violent friction and shock.

Last Update：2024-04-10 22:29:15